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KMID : 0043320090320101409
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Archives of Pharmacal Research
2009 Volume.32 No. 10 p.1409 ~ p.1415
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Inhibition of DNA Topoisomerases I and II and Cytotoxicity by Lignans from Saururus chinensis
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Son Jong-Keun
Kang Shin-Jung
Lee Yeun-Kyung
Seo Chang-Seob
Lee Chong-Soon
Lee Kyong-Seon
Jahng Yurng-Dong
Chang Hyun-Wook
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Abstract
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Thirteen lignans, erythro-austrobailignan-6 (1), meso-dihydroguaiaretic acid (2), sauchinone (3), 1’-epi-sauchinone (4), saucerneol D (5), manassantin B (6), manassantin A (7), nectandrin B (8), machilin D (9), saucerneol F (10), saucerneol G (11), saucerneol H (12) and saucerneol I (13), were isolated from the ethyl acetate extract of the roots of Saururus chinensis. Among these compounds, 5 showed potent inhibitory activities against DNA topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC50 values; 13, 12, 11, and 10μM, respectively) and HepG2 cell lines
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KEYWORD
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Saururus chinensis, Saururaceae, Lignan, Topoisomerase, Cytotoxicity
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